How the Placenta May Play into the Development of Schizophrenia

A new glance into our neurodevelopment poses that the placenta may play a key roll in a heightened risk for developing Schizophrenia. This study suggests that complications of the placenta may help to ‘turn on’ some of the genes that have been associated with diseases of the brain. Ones like ADHD, Autism, and Schizophrenia. For years now brain development has been the key hypothesis that points to the likelihood that Schizophrenia is actually a neurodevelopmental disorder. As opposed to a mood or personality disorder. Unfortunately, the biomechanisms on how this change occurs in the growing brain has remained misunderstood.

“While the subject of myth and ritual in many cultures, the placenta remains a scientifically neglected human organ, despite its essential role for supplying nutrients and chemicals critical for normal prenatal development. Indeed, the placenta is the only organ removed from a human body that is not routinely sent to the laboratory for examination.

For over a quarter of a century, brain development during pregnancy and shortly after birth has remained central to a hypothesis that Schizophrenia is a neurodevelopment disorder. However, the biological mechanisms involved were poorly understood. Previous studies have shown that genetic variants alone increase the odds of developing Schizophrenia by only a fraction, while early life complications during pregnancy and labor can increase the risk by up to two-fold. The Lieber Institute investigators studied over 2800 adult individuals, 2038 of whom had Schizophrenia, of various ethnic backgrounds from four countries, including the USA, Europe, and Asia. All had undergone genetic testing and were surveyed for obstetrical history information.”

Researchers have found a prominent link between genetic variations in Schizophrenia and serious pregnancy complications.

These hypotheses begin to help us understand the larger male than female ratio in developmental behavioral disorders, a list in which Schizophrenia is included. Males have a two to four times greater risk of developing these type of disorders and this study may help us see why. It’s become partly clear that placenta complications are more abundant in male birth.

Finding ways to understand the why and how people go on to develop something as serious as Schizophrenia can help us to intervene with high-risk individuals. This research, though at its beginning, could help us immensely in the future.

 

Burness. “Genes, environment, and schizophrenia: New study finds the placenta is the missing link: “Placenta may also hold the key to why neurodevelopmental brain disorders are more common in males.”

ScienceDaily. ScienceDaily, 28 May 2018.
www.sciencedaily.com/releases/2018.18052812400.htm

Advertisements

Common Device May Lead to Inexpensive and Accessible Test for Schizophrenia

People with Schizophrenia may have reduced electrical activity in the retina. Doctors have now begun testing this theory and it’s proving to be true. The RETeval is a handheld device used to record electrical activity from the retina. When testing patients experiencing acute psychosis, as compared to those who are experiencing none, the RETeval is allowing doctors to diagnose Schizophrenia. A test like this, which is both non-invasive and fast, could lead to a quick method for diagnosing psychosis. Something so simple would also be more affordable and fast acting. Allowing those in the most critical care access to the benefits of early intervention.
And while biomarkers in the eyes is a new way to look at psychiatric disorders, it is a promising one. Many people who have Schizophrenia often face years of psychosis and profound disability before a diagnosis. And for some waiting years after the onset makes treatment difficult or even ineffective. More seriously, many people living with undiagnosed Schizophrenia will die by suicide. Schizophrenia is the second most deadly mental illness and has the highest rates of suicide. Nearly one in ten people diagnosed will die by suicide, more than that will attempt. You can see why early intervention is a critical factor in the life expectancy of some with this disease.
Though the RETeval isn’t going to become a diagnostic tool any time too soon. It does promise hope for an accessible, affordable, and quick solution to the current layover time from onset to diagnosis.

 

Docia L. Demmin, Quentin Davis, Matthew Roche, Steven M. Silverstein. Electroretinographic anomalies in schizophrenia.. Journal of Abnormal Psychology, 2018; 127(4): DOI: 10.1037/abn0000347

Rutgers University. (2018, May 30). Promise of faster, more accessible schizophrenia diagnosis: Researchers explore eye function in schizophrenia as a window into the brain. Science Daily. Retrieved June 30, 2018 from:

wwww.sciencedaily.com/releases/2018/180530113131.htm

A Plan For Daily Self-Care

Daily Carry(with chronic illness)

It’s Okay

32708714_1677937958991530_5546944408743575552_n

Lessons from DBT: Wise Mind and Mindfullness.

I’ve done two solid years of DBT, the acronym of Dialectical Behavioral Therapy. And thanks to the groundbreaking work of Marsha M. Linehan, I’m here today. I can say, with utter truth, that DBT played a huge and integral part in my recovery, and has really shaped me into the person I am today. DBT took me from a place of impulsivity to one frequent peace with myself and my emotions. It wasn’t until after DBT that I began to apply a great deal of importance to inner peace. I want to share these things with people who may also benefit from them. With that said this is Lessons from DBT: Wise Mind and Mindfulness. 

Wise Mind is this beautiful intersection between Rational Mind and Emotional Mind. These two mind states can wreak havoc on your life in you exist too extremely in on or the other. For example, finding yourself only existing in Rational Mind, you might be cold, withdrawn, and lacking empathy. You could be slow to act and struggle to make decisions. While existing only in Emotional Mind you could find yourself acting emotionally impulsive. Jumping to conclusions and letting your emotions dictate your actions. You can see how an unbalanced life could quickly spiral out of control.

This is where Wise Mind comes in. Offering a way to draw from both mind states while not relying on one or the other too fiercely. When I started DBT I was trapped in Emotional Mind nearly all of the time. Acting on one impulsion and then another. Following my psychotic delusions to their end. And, ultimately, putting myself in danger.

I think Marsha Linehan put Wise Mind best when she says, “Wise Mind is like having a heart, everyone has one, whether they experience it or not.” I found, when learning about Wise Mind and becoming acquainted with it, it was best to start with breathing exercises. If you can imagine Wise Mind at the bottom of your stomach you can almost feel Wise Mind growing inside of you as you breathe. Sort of like the calm after the storm.

Try to recognize when your mind state is tipped in one direction or another. I great way to do this is practicing writing down what you are feeling when you are upset, feeling anxious, in crisis, or in my case, experiencing hallucinations. This way, once you have recognized your mind state Rational Mind or Emotional Mind, you will be able to take a step back and begin practicing breathing exercises. Imagining Wise Mind growing inside of your body and bringing with it a calm.

Try the 5-7-5 pattern (it’s a personal favorite). Which is inhaling on the 5, exhaling on the 7, and inhaling again on the 5. This exercise should be repeated for as long as you need it for and until you find yourself in a better place and you can think more clearly.

 

 

tumblr_orabipYacQ1uatsebo1_540